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Friday, 04 August 2017 Last modified on Friday, 04 August 2017
There is growing interest in examining the simultaneous effects of multiple exposures and, more generally, the effects of mixtures of exposures, as part of the exposome concept. Uncovering such combined effects is challenging owing to the large number of exposures, several of them being highly correlated. This paper describes a…
Wednesday, 17 May 2017 Last modified on Wednesday, 17 May 2017
With the start of summer in sight, HELIX will soon arrive at the completion of the second official part of the project – data generation and analysis. However, we are not done just yet! To allow us to present to you a most comprehensive set of results and associated implications,…
Tuesday, 16 May 2017 Last modified on Tuesday, 16 May 2017
We are pleased to present a short video in which our researchers explain how the HELIX project teaches us more about the environment-physical health relationship. In all, we hope to contribute to improving preventive disease strategies, which leads to lower health costs and a reduction of the environmental burden of…
Thursday, 04 May 2017 Last modified on Thursday, 04 May 2017
Reduction in the cost of genomic assays has generated large amounts of biomedical-related data. As a result, current studies perform multiple experiments in the same subjects. While Bioconductor’s methods and classes implemented in different packages manage individual experiments, there is not a standard class to properly manage different omic datasets…
Friday, 28 April 2017 Last modified on Friday, 28 April 2017
This study focuses on 1 H NMR spectroscopic analyses of urine, which in comparison to blood is a non-invasive biofluid to access, making it a more attractive choice for large-scale biological sampling in children. The influence of the sample collection time-point of the day on the metabolic phenotype was examined,…
Thursday, 17 November 2016 Last modified on Thursday, 17 November 2016
Maternal metabolism during pregnancy is a major determinant of the intra-uterine environment and fetal outcomes. This study characterizes the maternal urinary metabolome throughout pregnancy to identify maternal metabolic signatures of fetal growth in two Spanish subcohorts. It further explains potential sources of variation in metabolic profiles based on lifestyle and…

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