- What we do
- Project management
- Stakeholders
In six existing prospective birth cohort studies in Europe, HELIX will estimate prenatal and postnatal exposure to a broad range of chemical and physical exposures: persistent and non-persistent organic chemicals, metals, pesticides, environmental tobacco smoke, water contaminants, air pollutants, noise, UV radiation, and contact with green spaces.
Exposure models will be developed for the full cohorts totalling 32,000 mother-child pairs and biomarkers will be measured in a subset of 1,200.
Nested repeat-sampling panel studies (N=150) will collect data on biomarker variability and use smartphone-linked sensors to assess individual mobility, physical activity and personal exposure to air pollutants and UV radiation.
Omics techniques will determine molecular profiles (metabolome, proteome, transcriptome, epigenome) associated with exposures.
Statistical methods for multiple and combined exposures will provide exposure-response estimates for fetal and child growth, obesity, neurodevelopment, and respiratory outcomes.
Finally, a health impact assessment exercise will be conducted for combined early-life exposures.
Martine Vrijheid - martine.vrijheid[at]isglobal.org
Project CoordinatorDiana van Gent - diana.vangent[at]isglobal.org
Project Manager and contactCREAL - Centre de Recerca en Epidemiologia Ambiental
Parc Recerca Biomèdica de Barcelona
Doctor Aiguader, 88 - 08003, BarcelonaTel +34 932 14 7354
Fax +34 932 14 7301
BIHR
Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust (UK)
Prof. John Wright
Bradford Institute for Health Research is the research directorate for Bradford Teaching Hospitals NHS Foundation Trust and is a national centre for applied research in the UK with particular expertise in older people, stroke, quality and safety of health care and clinical trials. The Institute runs the Born in Bradford cohort, investigating the early origins of child and adult ill-health in 14,000 children (and their families) in Bradford.
Contributing personnel
John Wright
Pippa Bird
Lesley Fairley
Dan Mason
Rosie McEachan
Emily Petherick
Noortje Uphoff
Dagmar Waiblinger
Julian Walls